Tau-first and amyloid-first AD subtypes identified

New findings have added to the weight of evidence suggesting that some Alzheimer’s disease (AD) patients develop early-stage tau pathology before amyloid pathology.

Researchers from centers in London, UK, and Amsterdam, the Netherlands, used data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) to perform two analyses. They applied data-driven disease subtyping models to positron emission tomography (PET) and cerebrospinal fluid (CSF) measures of both amyloid and tau.