Sex-specific genetic variations do not explain why Parkinson's disease is more common in men than women

Takeaway

  • Common genetic autosomal variations do not explain sex-specific differences in Parkinson's disease prevalence.

Why this matters ?

  • Genome-wide association studies have identified numerous genetic risk factors for Parkinson’s disease, but the genetic causes of differences in disease prevalence between males and females remains unclear.

  • These findings, obtained using multiple large case-control cohorts, suggest that the prevalence disparity is not explained by differences in sex chromosomes, suggesting that environmental effects could contribute to Parkinson’s disease sex-specific etiology.