Seizure outcome in temporal glioblastoma surgery

Takeaway

  • Anterior temporal lobectomy (ATL), as a supra-total resection strategy, is associated with superior favorable seizure outcome following temporal glioblastoma (TGB) resection compared with gross-total resection (GTR).

Why this matters

  • Post-operative seizure freedom is an important secondary outcome measure in glioblastoma surgery, and recent clinical focus has been on ATL (resection beyond tumor limits visible on neuroimaging scans) as a potential epilepsy-surgical therapeutic approach; however, findings are uncertain due to data scarcity.

  • ATL-associated favorable seizure outcomes in patients with TGB is an encouraging finding; however, further study on larger cohorts and examination of neuropsychological effects is required since severe effects on quality of life potentially outweighing benefits may result, depending on resected brain regions.

International Medical Press is a global provider of independent medical education. Its mission is to provide healthcare professionals with high-quality, trusted medical information with the aim of helping optimize patient care.

No responsibility is assumed by International Medical Press for any injury and/or damage to persons or property through negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. Because of rapid advances in the medical sciences, International Medical Press recommends that independent verification of diagnoses and drug dosages should be made. The opinions expressed do not reflect those of International Medical Press or the sponsor. International Medical Press assumes no liability for any material contained herein.