Patterns of brain abnormalities in people with temporal lobe epilepsy

Takeaway

  • Using multimodal magnetic resonance imaging (MRI) scans with machine learning elucidates patterns of abnormality in people with temporal lobe epilepsy (TLE) who have a typically visually normal MRI.

Why this matters

  • About 10% of people with TLE do not respond to pharmacotherapy and neurosurgery; often, these people also do not respond to surgery due to a visually normal MRI scan where the epileptic tissue cannot be identified.

  • Using MRI with machine learning is a new method to potentially identify brain abnormalities in people with TLE who are resistant to pharmacotherapies and have a visually normal MRI.