Odor identification and discrimination as potential biomarkers for neurodegeneration in MS

Takeaway

  • The capacity to correctly identify odors (identification) and to discriminate them (discrimination) is associated with gray matter atrophy in regions related to olfactory function in patients with early-stage multiple sclerosis (MS).

Why this matters

  • The first longitudinal study to provide a direct link between the impairment of odor discrimination and identification, disability progression, and grey matter atrophy.

  • Dysfunction of olfactory qualities could act as a potential biomarker of both inflammation and subsequent neurodegeneration in patients with MS.