Novel MRI pattern found in children with myelin oligodendrocyte glycoprotein (MOG) antibodies

Researchers in Argentina have identified a novel neuroimaging pattern in children with myelin oligodendrocyte glycoprotein (MOG)-associated disorders (MOGAD).

Antibodies against MOG are found in more than 30% of children with a first demyelinating clinical event, according to Dr Silvia Tenembaum of the National Pediatric Hospital Dr Juan P Garrahan, in Buenos Aires, Argentina. Neuroimaging findings can vary widely among patients with MOGAD.

To better characterize MOG-related lesions, Dr Tenembaum and colleagues reviewed imaging data from 53 children with MOGAD treated at their institution. The goal was to determine the frequency and distribution of a novel neuroimaging feature, namely large inflammatory lesions with cystic changes.