Mild cognitive impairment reversion to normal cognition is linked to preserved cortical structure and glucose metabolism


  • People with mild cognitive impairment who revert to normal cognition have better preservation of cognitive function, cortical structure, and metabolism than non-reverters.

Why this matters

  • The mechanisms underlying reversion from mild cognitive impairment to normal cognition remain unknown; this unique study sought to identify the clinicopathological characteristics of reverters using clinical and in vivo brain imaging data from three well-established longitudinal cohorts.

  • This novel study provides significant information for mild cognitive impairment prognosis that could help to identify cognitive-preserving factors and develop cognitive-preserving therapies for people with mild cognitive impairment.