Takeaway
Microtubule-associated protein tau (MAPT) H1 haplotypes are associated with an increased risk for progressive supranuclear palsy (PSP), but a subset of haplotypes may be the driving force behind this association and also impact severity of tau pathology.
Why this matters
These results lead to better understanding of the contribution of individual MAPT H1 subhaplotypes to PSP, with the potential to act as biomarkers for disease onset and progression.