MAPT subhaplotypes and risk for progressive supranuclear palsy and tau pathology

Takeaway

  • Microtubule-associated protein tau (MAPT) H1 haplotypes are associated with an increased risk for progressive supranuclear palsy (PSP), but a subset of haplotypes may be the driving force behind this association and also impact severity of tau pathology.

Why this matters

  • These results lead to better understanding of the contribution of individual MAPT H1 subhaplotypes to PSP, with the potential to act as biomarkers for disease onset and progression.