Impact of oxaliplatin-induced peripheral neuropathy on quality of daily life.


  • Acute oxaliplatin-induced peripheral neuropathy (OIPN), together with the other side effects of chemotherapy, has a negative impact on daily quality of life (QoL) in patients with intestinal or pancreatic cancer.

Why this matters

  • Peripheral neuropathy is a major side effect of oxaliplatin, a first-line therapy for colorectal and other cancers. OIPN is dose-limiting, and addressing acute OIPN is of utmost importance, as these effects can progress to chronic neuropathy.

  • The results from this study confirmed that acute OIPN has an influence on daily QoL in patients treated with oxaliplatin and should be used as a basis for quantitative research to assess which symptoms are the most limiting and have the largest influence on QoL.