Identification of CDKN2A gene alterations associated with recurrent meningiomas

Takeaway

  • An undescribed p.(Ala148Thr) CDKN2A mutation in meningioma was significantly associated with recurrence and was never found in non-recurrent meningiomas.

Why this matters

    Meningioma treatment strategy relies on proper assessment of the risk of recurrence. The results from this study suggest that CDKN2A alterations may be biomarkers of recurrence in meningioma.