Glucocerebrosidase gene and severity of motor decline in newly diagnosed Parkinson’s disease

Takeaway

  • People carrying glucocerebrosidase gene variants have more severe motor disease impairment following diagnosis of Parkinson’s disease.

Why this matters ?

    To date, few studies have investigated the effect of glucocerebrosidase gene carrier status on motor decline in early phases of Parkinson’s disease. These novel findings reveal important clinical features of glucocerebrosidase gene-associated Parkinson’s disease, which could help to improve both individualized management and clinical trial design.