Development and maintenance of ocular dominance in mouse visual cortex requires Homer1a gene

Takeaway

  • Homer1a gene (H1a) and its interaction with mGluR5, a glutamate receptor, are required to establish contralateral ocular dominance (OD) in the primary visual cortex (V1) and to maintain OD after longer periods of monocular deprivation (MD).

Why this matters

  • Molecular mechanisms underlying the development and maintenance of OD are not well established.