Cortical iron and myelin changes suggest that Huntington’s disease pathogenesis begins 20 years before clinical onset

Takeaway

  • Early microstructural brain changes are found in carriers of the Huntington's disease gene several decades before disease onset.

Why this matters

    Investigators used novel state-of-the-art imaging techniques to examine early microstructural brain changes in Huntington's disease gene carriers before disease onset. By showing that microstructural changes occur many years before disease onset, this novel study provides new evidence that cortical iron and myelin play an important role in Huntington's disease pathogenesis.