Cortical atrophy begins as early as puberty in multiple sclerosis, researchers say

Researchers in Sweden have demonstrated that cortical atrophy occurs before symptom onset in patients with multiple sclerosis (MS), and can begin around the time of puberty.

Patients with MS often have reduced gray matter volume at diagnosis, indicating that neurodegeneration occurs before the onset of clinical symptoms. However, little is known about the time of onset and rate of atrophy over time.