Cognitive function in adult onset X-linked adrenoleukodystrophy

Takeaway

  • Depending on the phenotype, patients with adult-onset X-linked adrenoleukodystrophy (X-ALD) showed differences in cognitive function in various domains, including processing speed, attention and learning.

Why this matters

  • X-ALD is a rare genetic disorder with a varied adult-onset phenotype, from mild myelopathic forms (adrenomyeloneuropathy [AMN]) to severe cerebral variants (adult cerebral adrenoleukodystrophy [ACALD]).

  • More information on cognitive function in adult-onset X-ALD phenotypes would help inform treatment decisions and prognosis.