Changes in the microcirculation associated with functional decline in early Alzheimer’s disease

Takeaway

  • Changes in white matter microcirculation in early-stage Alzheimer’s disease (AD) are associated with pathological and functional decline; capillaries may therefore provide a suitable target for treatment in early disease.

Why this matters

  • Greater understanding of the contributions of amyloid-β (Aβ) and vascular pathology to the progression of early AD could enable successful development and targeting of therapies.