Autosomal dominant Alzheimer’s disease: an assessment of motor symptoms

Takeaway

  • People carrying the autosomal dominant Alzheimer’s disease (ADAD) mutation have a higher frequency of motor symptoms than non-carriers, correlating with increased amyloid beta (Aβ) protein deposition in the basal ganglia.

Why this matters

  • The link between motor symptoms and ADAD mutations indicates clinical assessment of motor symptoms should be included in evaluation of individuals from families with a history of ADAD.