Atrophy and cognitive profiles in older adults with temporal lobe epilepsy


  • Overlap of medial temporal lobe atrophy (TLA) and cognitive impairment (CI) was seen between older adults with temporal lobe epilepsy (TLE) and amnestic mild cognitive impairment (MCI).

Why this matters ?

  • Pathological brain aging is a particular concern for patients with TLE; however, whether the shared cognitive dysfunction observed in these and patients with amnestic MCI corresponds to similar cortical and hippocampal atrophy patterns is unknown.

  • Overlaps in brain atrophy and CI in older adults with TLE and MCI highlights potential issues of accelerated aging and comorbid Alzheimer’s disease in these patients, suggesting an urgent need for research to identify common pathology, and to target shared symptoms.

International Medical Press is a global provider of independent medical education. Its mission is to provide healthcare professionals with high-quality, trusted medical information with the aim of helping optimize patient care.

No responsibility is assumed by International Medical Press for any injury and/or damage to persons or property through negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. Because of rapid advances in the medical sciences, International Medical Press recommends that independent verification of diagnoses and drug dosages should be made. The opinions expressed do not reflect those of International Medical Press or the sponsor. International Medical Press assumes no liability for any material contained herein.