Summary Summary Short summary of a recent publication, written by scientific experts.

Alemtuzumab and stem cell transplantation versus non-induction therapies in multiple sclerosis

Takeaway

There is an increased incidence of thyroid disease with alemtuzumab (ATB), and of infection with autologous hematopoietic stem cell transplantation (AHSCT) compared with non-induction therapies in the treatment of patients with multiple sclerosis (MS).

Why this matters

In Sweden, ATB (monoclonal antibody, induces depletion and repopulation of CD52+ cells) and AHSCT are mainly used for aggressive relapsing MS; however, their widespread use is limited by concerns and uncertainty around their safety compared with other MS therapies.

The association of increased thyroid disease and infection risk with ATB and AHSCT complements current therapeutic knowledge, allowing clinicians and patients with MS to make more informed treatment decisions; and provides a basis for further study.

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