Ischemic stroke survivors are at high risk of stroke recurrence. In a study by researchers at Yale University and the Yale School of Medicine, a higher polygenic risk for increased LDL-cholesterol (LDL-c) was found to be associated with worse clinical outcomes after stroke.
This study analyzed clinical and genetic data from the Vitamin Intervention Stroke Prevention (VISP) clinical trial, which examined high-dose vitamins in stroke survivors. Genetic susceptibility to increased LDL-c was modeled through a polygenic risk score built with genetic data on 38 known genetic risk variants for LDL-c.